The Hammers were beaten 4-0 by the League One U’s despite having over £70million worth of talent on the pitch at the Kassam Stadium.
That result came just three days after Manuel Pellegrini’s side beat Manchester United 2-0 at the London Stadium.
West Ham sit fifth in the league and have lost just once, a 5-0 opening-weekend thrashing at home to Manchester City – who they sit a very respectable two points behind after six fixtures.
Bournemouth are just one point behind them in sixth after overcoming south coast neighbours Southampton last weekend for their first ever win at St Mary’s, though they also suffered humiliation in the cup as they lost at third-tier Burton Albion.
For the challenge of the Cherries, Pellegrini remains without centre-back Winston Reid and forward Michail Antonio due to a knee injury and a thigh problem respectively.
The Chilean boss is however boosted by the returns of three players in Dorset, with Manuel Lanzini set to return from an ankle knock after missing the last two matches.
Pellegrini said: “Manuel returned to work with the team over the last two or three days,” Pellegrini confirmed. “He has no pain in his feet. He doesn’t have any problems. He’s in the squad list.”
The Argentine playmaker is expected to replace summer signing Pablo Fornals, who has started West Ham’s last two matches but was below-par at Oxford.
Right-back Ryan Fredericks is also expected to shake off a knock sustained against United in order to replace Pablo Zabaleta, with Pellegrini having confirmed the “rest of the players are okay” aside from Antonio and Reid.
Also back is Arthur Masuaku, who was absent through suspension last weekend. But the fact he played 90 minutes in the week should mean Aaron Cresswell, who scored a stunning free-kick in the win over United, starts at left-back with Masuaku on the bench.
In between the pair, Issa Diop will retain his usual role while Angelo Ogbonna is expected to partner him over Fabian Balbuena as the Londoners seek a fourth successive top-flight clean sheet.
Ahead of them, captain Mark Noble is expected to partner Declan Rice in a two-man holding midfield, with Lanzini in the hole ahead of the pair.
On either flank, first-choice wingers Andriy Yarmolenko and Felipe Anderson will flank club-record signing Sebastien Haller, who looks to build on his tally of three goals in five league games.
Pellegrini has warned his side to be alert defensively against Bournemouth, saying: “It is a team that plays offensive football with normally two strikers. It is also a team that plays with one more [attacker] on the left side.
“We must know that we need to concentrate on defending but as always we are going to go for the three points. We’re going to attack from the first minute and try to add three points more.”
Callum Wilson has four Premier League goals this term and six in six against West Ham. Pellegrini added: “He is a very good player who is always scoring. He is a difficult player, very strong with very good movements.
“We will try not only to avoid him scoring but they also have the other Wilson in midfield, King and other players who can score. We must work as a team not focus on one player. They have many strengths.”
West Ham predicted line-up vs Bournemouth
4-2-3-1: Fabianski; Fredericks, Diop, Ogbonna, Cresswell; Rice, Noble; Yarmolenko, Lanzini, Anderson; Haller.