City beat their cross-city rivals in both fixtures last season and will be looking to heap more misery on Ole Gunnar Solskjaer’s men.
A 3-1 victory at the Etihad in November last year saw City keep their place at the top of the Premier League.
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And their 2-1 win at Old Trafford went a long way to helping Pep Guardiola’s side retain their title.
Both sides will face off in the season’s first Manchester derby on December 7, 2019 at the Etihad.
The reverse fixture takes place on March 7, 2020 at Old Trafford.
United will be desperate for a better showing this time around after a miserable end to the last campaign.
They failed to win any of their final five games of 2018-19 and slumped to sixth in the Premier League as they missed out on Champions League football.
Solskjaer is hoping their end-of-season struggles will inspire them to put things right when the new campaign kicks off.
“I’ve only been here five months but you get more energy off working and sometimes, sadly but it’s true, you get more energy when it goes against you,” he said last month.
“You get more energy because you’re determined to come back a better team and a better coach, to help the players improve and be even better.
“Yeah it’s nice, winning, don’t get me wrong. But when you get a season like we’ve had, I think everyone wants to show what we can do, because they’re proud players and we’re proud coaches.
”You can’t forget [about last season]. You have to learn from your mistakes as well. We want to learn more from what we did right.“
Meanwhile, midfielder Nemanja Matic has urged his team-mates to be ready from the very start of the new campaign and to work to ensure they are correctly prepared both mentally and physically.
“I think we need to be focused from the first day, to prepare physically and to be ready mentally for the season which is in front of us,” he said.
“We must think positively. We want to win trophies, so I think everyone needs to be ready.
“Last summer, because we had the World Cup, we had a shorter holiday and didn’t have as much time to rest.
“This time I think we will have more days off, so I think by the start of July we’ll be in a good mood.”
After claiming the FA Cup and Carabao Cup as well last season to complete a domestic treble, Guardiola insists he will be prioritising the league over Champions League again.
“The league is always the most important championship,” he said.
“It makes you happier because as you win a lot, on Sunday, Monday or Tuesday, you are happy. When you lose in the Champions League, you are f**ked for two days. When you go badly in the league you are f**ked many more days.”
All fixtures subject to change.